How much agmatine should i take

In one research study on the treatment of neuropathic pain in humans, Agmatine powder was administered at a dosage of between 1. Individuals taking Agmatine sulphate for the nootropic effects typically take between to mg per day.

Individuals using it for the treatment of pain or for bodybuilding and athletic training generally take dosages at the higher end of the range. As a pre-workout supplement, the best way to use product is to take it approximately minutes before a workout. For those looking to take this dietary supplement for its cognitive or analgesic effects, it is typically divided into smaller doses throughout the day.

According to online reports, Agmatine has low oral bio-availability when consumed alongside other proteins. It may be better absorbed from the gastrointestinal tract if consumed on its own and not with food. Depending on your individual goals, your daily Agmatine supplement may be stacked with other ingredients to achieve greater benefits.

For athletes, bodybuilders and endurance runners, a common combination is a mg Agmatine dosage with 2. In research studies, Betaine has been shown to increase nitric oxide production levels and improve lean muscle mass as well as bench press strength among exercise-trained males.

According to studies conducted so far, it appears that Agmatine Sulfate is safe even in relatively high doses. While there have been few studies conducted thus far, they have not shown any side effects to be associated with this supplement. If you follow the recommended Agmatine sulfate dosage protocol and do not have any pre-existing contraindications for use, the risk of serious adverse effects is very low. In animal studies, this compound has been observed to promote vasodilation, which is the dilation widening of blood vessels.

This can have benefits for circulatory function and blood flow, but may also cause a drop in blood pressure. Consult with a doctor before using if you have been diagnosed with hypotension or low blood pressure.

Consumption of Agmatine sulphate at high dosages for long periods of time may also cause stomach discomfort or gastrointestinal distress. In one study in which 3. Some bodybuilders have also reported increased appetite and weight gain when using this supplement. In one study on rats, this supplement was found to increase carbohydrate intake in rats that were satiated, and not hungry. However, in another study involving rats force-fed while taking Agmatine, there was actually a reduction in body weight gain reported.

This may be due to a body re-composition effect. While some online sources suggest that using Agmatine during a fat loss diet may be counter-productive, this result suggests that there could be benefits for fat loss. More research is needed to determine the safe upper dosage limit for Agmatine powder. There have been limited studies examining the effects of this nutritional supplement at dosages greater than 2.

There are a large number of potential benefits associated with Agmatine Sulfate related to sport nutrition, mental well-being, pain reduction and cognitive health. Agmantine is also used by individuals taking Glutamatergic Ampakine nootropics that want to reduce the risk of excitatory neurotoxicity. Compared to the amino acid Arginine, significantly less is known about the mechanisms of this natural brain chemical.

However, it appears to exhibit many similar effects such as increasing nitric oxide synthesis and blood flow, improving insulin response and boosting growth hormone levels. This dietary supplement is continuing to be researched for its possible anti-aging and life extension or longevity promoting benefits. Agmatine is typically used at a dosage of 1. This supplement is considered safe, but there have not been many studies done on humans taking more than 2.

Individuals should avoid taking too much or super-loading with this dietary supplement to reduce the risk of adverse effects. Agmatine is contained in fermented foods produced by bacteria like beer, wine and instant coffee.

The concentration of agmatine would be very low, far lower than in agmatine sulfate supplements. Although agmatine is derived from l-arginine, an essential amino acid, they do not provide the same health benefits. The body needs arginine because it supports many vital bodily functions, but taking arginine supplements does not exhibit the same effects as agmatine. Arginine can convert directly into nitric oxide, whereas agmatine cannot.

However, agmatine can have a positive effect on nitric oxide levels and muscle pumps by way of other mechanisms. The authors of this report undertook to assess their own health status during ongoing consumption of a high daily dosage of oral agmatine over a period of years. A daily dose of 2.

Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. Supplementation should not exceed 6. Agmatine is not absorbed well when taken with dietary protein, because it uses the same transporters as arginine.

Further research is needed to determine if oral agmatine supplementation provides the same benefits as were observed in animal studies. Become an Examine Member to get access to the latest research. Understand the whole body of nutrition and supplement evidence at a glance.

The Human Effect Matrix summarizes human studies to tell you what effects Agmatine has on your body, how much evidence there is, and how strong these effects are. To unlock the full archives of our Study Database and research analyses, become an Examine Member today. Clonidine-displacing substance, 4- aminobutyl guanidine, Decarboxylated arginine. L-Arginine parent structure. Cannabinoids such as marijuana as agmatine enhances signalling through the cannabinoid CB1 receptor.

Alcohol withdrawal appears to reduce symptoms. Although at this moment in time agmatine appears to be pretty nontoxic, there is insufficient toxicology testing for superloading. It may be prudent to stick within the 2,mg dosage that has been used in humans. Get our free 5-day course on the essentials of supplementation. At Examine, our incentives line up with yours — getting unbiased information.

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Arm yourself with the knowledge you need to make the right decisions about your health. Click here to see the full set of research information and references for Agmatine. If using any pharmaceuticals or drugs given to you by a doctor or received with a prescription, you must consult with the doctor in question or an equally qualified Health Care Professional prior to using any nutritional supplementation.

If undergoing medical therapies, then consult with your respective Therapist or Health Care Professional about possible interactions between your Treatment, any Pharmaceuticals or Drugs being given, and possible nutritional supplements or practices hosted on Examine. Join Examine. Having an ingredient manufactured in China is standard. HPLC high-performance liquid chromatography tests for the percentage of an analyte in this case agmatine sulfate found in a sample.

However, an HPLC test can yield a different assay percentage from test to test for the same sample. This is due to the margin of error and other testing factors not related to the actual purity.

Large brands have their agmatine produced in an FDA registered facility. However, you may not have any luck if you ask them for their lab test results. These brands have much to lose if a competitor tries to use their lab or one of their upstream suppliers.

Some brands use third-party packagers. These copackers or private label intermediaries use their own ingredients and may not release testing results to their B2B customers.

Even small vendors are wary of giving away their labs or lot numbers. A lot number can distinguish a supplier since suppliers have common beginning or ending number or letters, or have a common lot number taxonomy.

Unless you are willing to pay a much higher price for ingredients from large brands—and also trust their quality without lab results—then going with a smaller vendor requires some level of diligence. If a small vendor only provides a COA from the ingredient manufacturer from China , then they probably lack an adequate quality management system.

These manufacturer-COA-only vendors are merely arbitraging middlemen who buy ingredients from a Chinese market, repackage them, and then sell them in a US market.

If a small vendor can provide a test from the US lab, then this is a step in a right direction. Does the person behind the company have a history of trustworthiness in selling supplements, or are they completely new to this industry? To reduce moisture, ensure your tub or bag of agmatine is properly sealed after each use. Adding a desiccant to your powder will also help reduce moisture. According to CGMP guidelines , unless a vendor conducts stability testing on their product, they cannot put an expiration date on their label.

This 2-year generalization assumes that you store it in a cool, dry location and that the container remains sealed when not in use.

Agmatine sulfate is a fine, white powder of moderate density.